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The primary goal for patients with primary hyperoxaluria is preventing the accumulation of calcium oxalate. It is important to seek medical care that will take into account the patients needs, the type and severity of disease and how well the patient responds to various treatments. Patients should be closely monitored by their physician to measure the following treatments:

  • Medications
    Pyridoxine (Vitamin B6) in prescription-level doses is capable of reducing the amount of oxalate produced by the liver in approximately half of the patients with Type 1 Primary Hyperoxaluria. In some patients the amount of oxalate produced is reduced to normal. Every patient with Type 1 Primary Hyperoxaluria should be tested for pyridoxine responsiveness. Those that benefit should continue to take pyridoxine on a regular, daily basis. Neutral phosphates and citrate are also effective in reducing the formation of calcium oxalate crystals and stones in the urine. Magnesium is sometimes used.  

  • High fluid intake
    Hyperoxaluria patients who do not have kidney failure will need to increase the amount of water or other liquids they drink. The extra fluid is intended to keep the kidneys flushed, to help prevent the build up of oxalate and prevent formation of kidney stones.  

  • Dietary modifications
    Dietary restrictions are less important in primary hyperoxaluria than they are in most stone forming diseases. Nonetheless, it is recommended that patients with primary hyperoxaluria avoid a high dietary oxalate intake. Patients with acquired, absorptive or enteric hyperoxaluria will need to follow a diet low in oxalate. Those with enteric hyperoxaluria will also need to limit fat in their diet.  

Kidney Stone Management
Kidney stones that cause pain or other symptoms or are obstructing the flow of urine from the kidneys may require removal or fragmentation by lithotripsy (ESWL). It is recommended to seek professionals experienced in stone removal procedures.

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