OHF Funded Grants
Following is a chronological timeline, reviewing the continued progress of OHF research.

2011 Research Studies

Grants

• HDAd-mediated gene therapy for primary hyperoxaluria type 1
  Nicola Brunetti-Pierri, MD
  Fondazione Telethon
  Rome, Italy
  
   

  Phenotypic changes associated with PH3
  Ross P. Holmes, PhD
  Wake Forest University Health Sciences
  Winston-Salem, NC
  

   

  Biochemical and structural studies of variant forms of KHGA identified in type III primary hyperoxaluria
  W. Todd Lowther, PhD
  Wake Forest University Health Sciences
  Winston-Salem, NC
  

 

2010 Research Studies

Grants

• Probiotic Treatment of Primary Hyperoxaluria
  Marguerite Hatch, PhD
  University of Florida
  Gainesville, Florida
  
   

  Patient-specific pluripotent cells to derive hepatocytes for treating Primary Hyperoxaluria-1
  Namita Roy-Chowdury, PhD
  Albert Einstein College of Medicine of Yeshiva University
  Bronx, New York
  

 

2009 Research Studies

Grants

• Genetic Studies into atypical hyperoxaluria
  Robert Kleta, MD, PhD, FASN, FACMG
  University College London
  London, United Kingdom
  
   

  Human KHGA: a novel target for the treatment of hyperoxaluria
  W. Todd Lowther, PhD
  Wake Forest University Health Sciences
  Winston-Salem, North Carolina
  

   

  Towards the pharmacological treatment of primary hyperoxaluria: multiply-transformed CHO cells as a model system
  Christopher J. Danpure, BSc PhD FMedSci
  University College London
  London, United Kingdom
  

  • Final Report: Towards the pharmacological treatment of primary hyperoxaluria: multiply-transformed CHO cells as a model system

 

2008 Research Studies

Grants

• Molecular insights into Primary Hyperoxaluria Type 1
  Carla Voltattorni, PhD
  University of Verona
  Verona, Italy
  
  • Final Report: Molecular Insights into Primary Hyperoxaluria Type I

 

• Use of differential scanning fluorometry to identify ligands that stabilize AGT
  Chandra Tucker, PhD
  University of Duke
  Durham, North Carolina
  
  • Final Report: Use of differential scanning fluorometry to identify ligands that stabilize AGT

 

• Liver Cell Transplantation for Primary Hyperoxaluria
  Namita Roy-Chowdury, PhD
  Albert Einstein College of Medicine of Yeshiva University
  Bronx, New York
  
  • Final Report: The Utility of Oxalobacter in Enhancing Enteric Oxalate Excretion in Primary Hyperoxaluria Type 1

 

2007 Research Studies

Grants

• The Utility of Oxalobacter in Enhancing Enteric Oxalate Excretion in Primary Hyperoxaluria Type 1
  Marguerite Hatch, PhD
  University of Florida
  Gainesville, Florida
  
  • Final Report: The Utility of Oxalobacter in Enhancing Enteric Oxalate Excretion in Primary Hyperoxaluria Type 1

 

2006 Research Studies

Grants

• Identification and characterization of pharmacological chaperones for AGT
  Chandra Tucker, PhD
  Duke University
  Durham, North Carolina
  
  • Final Report: Identification and Characterization of Pharmacological Chaperones for AGT
   
  

  Mutation-Specific Correction of Aberrant AGT Phenotypes in Transgenic Knockout Mice
  Eduardo Salido, MD, PhD
  Hospital Universitario Canarias / FRC Investigacion
  Spain
  

  • Final Report: Mutation-Specific Correction of Aberrant AGT Phenotypes in Transgenic Knockout Mice

 

2005 Research Studies

Grants

• Regulation of Renal Epithelial Cell Surface Calcium Oxalate Crystal Binding Molecule
  Vivek Kumar, PhD
  Mayo Clinic
  Rochester, Minnesota
  
  • Final Report: Regulation of Renal Epithelial Cell Surface Calcium Oxalate Crystal Binding Molecules”
  
  
  
• Hyaluronan and crystal retention
  Carl F. Verkoelen, PhD
  Erasmus Medical Center Rotterdam
  Rotterdam, The Netherlands
  

 

2004 Research Studies

Grants

• An investigation into the relationship between in vitro stone growth rate, oxalate and crystal size distribution
  John P. Kavanagh, PhD
  South Manchester University Hospitals Trust
  Manchester, England
  
  • Final Report: An investigation into the relationship between in vitro stone growth rate, oxalate and crystal size distribution
  
  
• Glycolate Oxidase Inhibition and the Treatment of Primary Hyperoxaluria Type 1
  Ross Holmes, PhD
  Wake Forest University Health Sciences
  Winston-Salem, North Carolina
  
  • Final Report: Glycolate Oxidase Inhibition and the Treatment of Primary Hyperoxaluria Type 1

 

2003 Research Studies

Grants

• Establish A Clinical Center for Primary Hyperoxaluria
  Dawn S. Milliner, MD
  Mayo Foundation
  Rochester, Minnesota
  
  
• mRNA Expression of Renal Oxalate Transporters in Hyperoxaluria
  Mike L. Green, PhD
  University of Florida
  Gainesville, Florida
  

 

2002 Research Studies

Grants

• The Role of Tubule Epithelial Cell Pericellular Matrix Formation in the Retention of Calcium Oxalate Crystals
  Carl Verkoelen, PhD
  Erasmus Medical Center Rotterdam
  Rotterdam, The Netherlands
  
  • Final Report: The Role of Tubule Epithelial Cell Pericellular Matrix Formation in the Retention of Calcium Oxalate Crystals
  
  
• Towards a Better Understanding of the Metabolic Profile of the Hyperoxalurias
  Gill Rumsby, PhD, MRCPath
  University College London Hospitals
  London, England
  
  
• AGT Structure, Folding and Stability: Drug-Induced AGT Stabilization as a Treatment for Primary Hyperoxaluria Type 1
  Christopher Danpure, BSc, PhD
  University College London
  London, England
  
  • Second Year Report: AGT Structure, Folding and Stability
  • Final Report: AGT Structure, Folding and Stability

 

2001 Research Studies

Grants

• Renal Oxalate Secretion And Proximal Tubule Injury
• Intracellular Oxalate Concentration: Isotopic And Fluorometric Determination
• Expressions And Characterization Of Oxalate Decarboxylase. A Potential Therapeutic/Prophylactic Agent For Hyperoxaluria

 

Final Reports

• Renal Oxalate Transport In An Animal Model Of Hyperoxaluria
• Genetic Analysis Of Primary Hyperoxaluria Type 2
• Calcium Oxalate Crystal Nucleation Onto Kidney Cells

 

2000 Research Studies

Grants

• Structure of AGT and the Rational Search for Hyperactive AGT Variants
• Characterisation of Human Aglycolate Oxidase and Investigation of its Possible Role in Atypical Primary Hyperoxaluria
• Alanine-Glyoxylate Aminotransferase Deficient Mouse as Model for Gene Therapy of Primary Hyperoxaluria

 

 

1999 Research Studies

Grants

• Renal Oxalate Transport in an Animal Model of Hyperoxaluria
• The Genetic Basis of PH2
• Elimination of Oxalate in Hyperoxaluric Conditions and Renal Failure
• Calcium Oxalate Crystal Nucleation onto Renal Cells

 

 

1998 Research Studies

Grants

• Investigations into the Phenotype and Genotype of Atypical Primary Hyperoxaluria

 

 

1997 Research Studies

Grants

• Treatment of PH1 with OTZ

 

 

Overview | Grant Applications | Funded Grants
Patient Registry | Scientific Advisory Boards